In vitro and in vivo evaluation of gastroretentive floating drug delivery system of ofloxacin
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چکیده
منابع مشابه
Formulation and In-Vitro Evaluation of Gastroretentive Drug Delivery System Containing Ofloxacin
Sustained release gastroretentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal (GI) tract and improve the bioavailability of medications that are characterized by a narrow absorption window. A new strategy is proposed for the development of gastroretentive dosage forms for ofloxacin preferably once daily. The design of the delivery sy...
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Rosigilitazone maleate is an anti-diabetic agent is used in the management of Type-II diabetes mellitus. The present investigation concerns the development of the sustained release floating matrix tablets which are designed to exhibit a prolonged gastric residence time and controlling the drug release from the dosage form. This system is useful particularly for achieving controlled plasma level...
متن کاملFormulation and in vitro evaluation of ofloxacin as floating drug delivery system
The present study outlines a systematic approach for designing and development of Ofloxacin floating tablets to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablets of Ofloxacin have shown controlled release thereby proper duration of action at a particular site and are designed to prolong the gastric residence time after oral administration. Floating tablets of Of...
متن کاملFloating Drug Delivery of Nevirapine as a Gastroretentive System
A multiple-unit floating drug delivery system based on gas formation technique was developed, in order to prolong the gastric residence time and to increase the overall bioavailability of the dosage form. The floating bead formulations were prepared by dispersing nevirapine together with calcium carbonate in a mixture of sodium alginate and hydroxypropyl methylcellulose solution and then drippi...
متن کاملHollow microspheres for gastroretentive floating- pulsatile drug delivery: preparation and in vitro evaluation.
PURPOSE A multiparticular floating-pulsatile drug delivery system was developed for time and site specific drug release of piroxicam. A blend of floating and pulsatile principles of drug delivery system would have the advantage that a drug can be released in the upper GI tract after a definite time period. METHODS Hollow microspheres were prepared by the emulsion solvent diffusion method usin...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical Sciences
سال: 2013
ISSN: 1818-0876
DOI: 10.1016/j.ajps.2013.07.025